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Adding Value to Allele Data

In late winter at the Advances in Genome Biology and Technology (AGBT) scientific meeting in Marco Island, Fla., a coalition of 13 life science...

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A New Hope for Pancreatic Cancer

It’s a sad fact that most people diagnosed with pancreatic cancer feel their situation is hopeless. According to the National Cancer Institute, nearly 47,000...

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Precise with Mice

A collaboration between the Jackson Laboratory (JAX) and six academic centers has garnered a five-year, $10 million grant from the National Institutes of Health...

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A Conversation with Werner Verbiest

Werner Verbiest has spent the better part of the last 25 years in roles focused on designing better diagnostics for a range of diseases....

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Fine-tuning donor-patient organ matching

The International Genetics & Translational Research in Transplantation Network (iGENETRAiN) and commercial collaborator Affymetrix have together embarked on a genome-wide association study. The aim is to identify specific genetic variants that may...

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Finding the markers for a broken heart

PHOENIX – Research conducted at the Translational Genomics Institute (TGen) and the Barrow Neurological Institute has identified, for the first time, genes associated with stress-induced cardiomyopathy (SIC), a...

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OME-ing in on precision wellness

Pathway Genomics’ OME personalized wellness app leverages Watson’s cognitive computing In early January at the Consumer Electronics Show in Las Vegas, Pathway Genomics announced the closed-alpha release of...

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Glimpsing the future: New immune-based therapies for multiple myeloma.

Over the last year, the U.S. FDA approved a flurry of new drugs for use in multiple myeloma, a cancer that affects the bone...

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The Mutual Benefits of Rare Disease Research and Precision Medicine

Precision medicine seems tailored to the study of rare diseases: at least 80 percent of them arise from genetic variations, and (though not always the case) show varying...

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Diagnosing Rare Disease

A few days after the world celebrated Rare Disease Day, an international effort to raise awareness of rare diseases, UK-based Congenica, a company that offers clinical interpretation of genome sequence...

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Clinical Conundrums

Early this year, backed by a 3-year, $1.5-million grant from the Sohn Conference Foundation, Columbia University Medical Center announced plans to provide genome sequencing to...

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Liquid Biopsies Bleed Into Clinical Use

Technologies that can detect cancer in circulating blood have proliferated over the past few years, but proof of their prowess in the clinic has been...

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Companion Diagnostics – a Burgeoning Market

Since the first drug requiring a companion diagnostic test was approved by the U.S. Food and Drug Administration (FDA) in 1998, the global market for companion...

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The Race To Collect Genomes

In April, the precision medicine field got what researchers hope is a shot of adrenaline with the announcement by AstraZeneca that it will sequence the genomes...

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Ruminations on the Precision Medicine Leaders Summit: The Gordian Knot Connectivity of Stakeholders

The Inaugural Precision Medicine Leaders Summit (PMLS) was held in San Diego, California, on August 10-12th 2016 (www.precisionmedicineleaderssummit.com.) Currently there is a frenzied cacophony...

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The Current Developments Being Made in Cancer Immunotherapy

At the recent Precision Medicine Leaders Summit, the current developments being made in Cancer Immunotherapy were discussed on one of the many roundtables organised...

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Taking Proteomics to Heart

Coronary heart disease (CHD) is enormously widespread, affecting some 6% of US the population and killing 370,000 people annually and portending a heart attack,...

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Blood Donors Seen as Saviors for Precision Medicine

In early October, with a bandage on her arm after donating a pint of type O negative blood, Erin Elliott earned her “gallon pin”...

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Precision and Accuracy in Medicine: the Case of “Ovarian” Cancer

While researching our new books on women’s and men’s cancers, we made a rather startling discovery: what everyone refers to as ovarian cancer doesn’t...

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A Personalized Twist For Oncolytic Vaccines

Prospects for using viruses to fight cancer got a huge boost in late 2015 when the US Food and Drug Administration granted its first-of-a-kind...

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PRECISION MEDICINE: The Center for Individualized Medicine, Mayo Clinic

In its 150-year history, the Mayo Clinic has stayed true to its patient-centered model of care. That same vision has guided the trajectory of...

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A Genomic Mandate

In 1989, a young man affected with hemochromatosis, a genetic disorder of iron metabolism, told this story: “I have been successfully treated with low...

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The first challenge of any population-scale research study is building a cohort of engaged participants.

The first challenge of any population-scale research study is building a cohort of engaged participants. But once that major feat is accomplished, there’s a...

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Personalized Medicine at FDA: 2016 Progress Report

If new drug approvals are any indication, personalized medicine is progressing steadily despite ongoing challenges in regulation, reimbursement and clinical adoption. The Personalized Medicine...

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The Diagnostics Year in Review – 2016

A patient has nothing without an accurate and timely diagnosis. Diagnostics are the glue that holds the healthcare system together. An inaccurate, missed or...

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A Conversation with Stephen J. Ubl

Stephen Ubl is president and chief executive officer of Pharmaceutical Research and Manufacturers of America (PhRMA), which represents America’s leading biopharmaceutical research companies. Mr....

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PRECISION MEDICINE CENTER PROFILE: The Jackson Laboratory

The Jackson Laboratory (JAX) is living proof that translational genomic medicine is not the unique domain of academic hospitals. Founded in 1929 as a...

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Why diagnostic companies need to control their own market.

It has been nearly 20 years since what most consider to be the advent of Precision Medicine, when two targeted therapies (Herceptin and Gleevec)...

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California Paves the Way for State Efforts in Precision Medicine

It all started with a few lines in the California governor’s 2014 State of the State address: “Just as California has led the way...

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A Conversation with Norma Nowak.

Norma Nowak got hooked on the excitement and the promise of the Human Genome Project more than three decades ago and never looked back....

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Economics for Diagnostics- Why Paying for Value is Necessary to Drive Market Success and Uptake.

Historically, diagnostic testing in healthcare has been bucketed as a commodity- cheap, frequent, and easy. This concept was born from run-of-the-mill testing: metabolic panels,...

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Precision Pathology

He entered the stage with a shirt reading “Sequence Me”. The other panelists were dressed in business attire, as was the moderator. This was...

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Precision Medicine: Advancing Patient Care through Genomic Data

A fundamental shift in medical education is needed in order for doctors and patients to benefit most from advances in precision medicine and information...

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Do Algorithms Dream of Genomics Sheep?

Artificial Intelligence & Machine Learning – What’s the Difference? Genomics has been the catalyst in the information revolution that is sweeping across healthcare and...

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Is FDA Regulatory Flexibility an Oxymoron?

The title of this column poses a critical question that goes to the heart of Precision Medicine’s prospects to effectively meet its promise to...

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PMLS 2017 – Conference Highlights

In reviewing the agenda for this year’s conference, one would imagine another event organized to discuss what we have been talking about for few...

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Widening the Path of Precision Cancer Medicine

How DarwinHealth’s protein-hunting algorithms are helping the company advance cancer therapy and fill the gaps left by more traditional, gene-based methods

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Conference Report

There is a pressing need to better represent ethnic diversity with genomic resources — and in particular to do so in a way that...

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The Precisionist

The trouble with the future is that it usually arrives before we are ready for it,”said 92-year old Arnold H. Glasow in 1995

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The Olive – A Very Personal Medicine

I was once oblivious to the significance of the olive. As a child it was a color – a pastel shade of green –...

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Deal or No Deal? Legal and Regulatory Considerations In the Business of Precision Medicine

Precision Medicine is rapidly taking a larger and larger share of new therapeutic product approvals as industry and the FDA are gaining a more...

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Beyond The Economics

In a sense, when we have been talking about the goal of Precision Medicine, we have been discussing the value of diagnostics, with little...