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9 Essential Models to Predict the Future of Precision Medicine

As a quarter century follower of personalized medicine, the recent progress and pronouncements on precision medicine are greatly appreciated. Despite extraordinary complexities new ‘omics...

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Precision Medicine: The Importance of Correctly Matching the Tool to the Task

his year, on April 16th the Personalized Medicine World Conference (PMWC) made its debut in the UK. Attendee’s benefited from new insights behind the...

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High Resolution: Bringing a Sharper Focus to Precision Medicine Through Design

With so much attention focused on new ways to collect, combine, and mine health data, it can be easy to overlook the critical need...

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Paths to Precision Medicine: A Perspective

Cancer is a complex, heterogeneous disease, driven by multiple molecular pathways. There are hundreds of known oncogenes, which arise in myriad combinations, making every...

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Methods Towards Clinical Actionability of Next Generation Sequencing

Precision Medicine necessitates continuously measuring the certainty with which the right patient receives the right treatment at the right time. Common clinical presentations are...

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Electronic Health Systems: Golden Mine for Precision Medicine?

Precision medicine is an emerging field whose relevance is destined to grow at a pace, that at least in part, depends on the concomitant...

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Blood-Based Companion Diagnostics

Since the seminal reports of the utility of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) in evaluating a cancer patient’s response to...

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Epigenetic Therapies, Immune Therapies, and Anti-Angiogenic Therapies: The Triad of Oncology. Angiogenesis: Cause or effect?

Advances in technology have allowed medical providers to customize healthcare with medical decisions, practices, and therapeutics being tailored to the individual patient. Through the...

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Pharmacovigilance and Data for Precision Medicine.

There is plenty of chatter surrounding ‘data driven discovery’ currently, yet do those authors, bloggers and conference speakers all talk of the same thing? Could...

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Cancer genome sequence data combined with incidence statistics suggests large numbers of patients could benefit from off-label therapies.

Targeted molecular therapies offer the hope that they can be used in any disease that carries the specific molecular aberration being targeted. Combining data on...

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Metabolomics, The Iceberg of Complexity and Clinical Utility

The genomic revolution continues to deliver research and clinical breakthroughs (CRISPR/Cas, WGS) that suggest greater precision and prediction is just ahead. And despite extraordinary complexities proteomics...

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The Computational Network Imaging Frontier: Relevance for Digital Biomarkers in Precision Oncology.

Cancer treatment is no doubt the greatest of the big challenges in the newborn field of Precision Medicine. As an effect of advances in imaging...

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The Dawning of Stem Cells in Precision Medicine.

Stem cell research has been around since the 1860’s . Fast forward a hundred years to the 1960’s with the advent of the bone...

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Metastatic Melanoma: A New Era of Treatments

Historically, the prognosis for metastatic melanoma has been poor. Patients with metastatic disease have a median survival of 6-9 months and less than 10%...

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Innovative Methodologies to Drive Enrollment of Molecularly Defined Patient Populations for Diagnostic- Enabled Basket Studies

Today, the genomic profile of a patient’s tumor may be as important, if not more so, than the tissue of origin. Patients whose tumors...

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Understanding and Managing Stress: Perspectives from in vivo Quantum Biology

Stress is a type of reaction to a stimulus that disturbs our physical and mental equilibrium. Chronic stress is an escalating health problem that...

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Genome Engineering Via CRISPR-Cas Systems: Inserting the “Precision” in Precision Medicine

Genomes encode the instructions for life forms. The ability to change this code in living cells can enable manipulation of organismal function and development....

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Clinical Trial Technologies for Precision Medicine: The Current State of the Art

Precision medicine is positioned to revolutionize the healthcare landscape, and the utilization of advanced clinical development technologies is key to supporting precision medicine trials....

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Digital Health: Its Impact on the Genomics Industry

Electronic health records are “digital” and their use is widespread today. But, relative to the care patients received ten years ago, has healthcare for...

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Understanding and Managing Stress: Perspectives from in vivo Quantum Biology

Stress is a type of reaction to a stimulus that disturbs our physical and mental equilibrium. Chronic stress is an escalating health problem that...

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Cancer Metastatic Processes Contextualized by Networks: Role of Entropy, Symmetry and Controllability

Networks are pervasive in biomedicine, especially in the realm of experimental studies and computational applications. Their relevance reflects the ability to model systemic complexity....

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Scaling-up NGS Secondary Analysis Using Field Programmable Gate Arrays in the Cloud

Next-generation sequencing (NGS) holds the promise of tailoring diagnosis and treatment to individuals based on their genetic makeup. As the price of sequencing drops,...

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Precision Oncology Trials: A Look Ahead

Life science sponsors are incorporating patient genetic and genomic information in clinical development programs to find the most accurate and effective treatments for patient...

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Unraveling the Microbiome’s Complex Role in Immunotherapy

A growing body of evidence has shown that the microbiome influences both the development of disease and patient response to therapy. In the field...