Genome Engineering Via CRISPR-Cas Systems: Inserting the “Precision” in Precision Medicine

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Genomes encode the instructions for life forms. The ability to change this code in living cells can enable manipulation of organismal function and development. Though this was previously challenging, the recent advent of RNA-guided effectors derived from the clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) systems has dramatically transformed our ability to engineer genomes.

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