Precision Medicine in Infectious Diseases: Changing the treatment paradigm for bacterial infections to end the Antimicrobial Resistance Crisis.
Precision medicine is often associated with oncology where the ability to screen and select patients based on a particular mutation is critical for use and efficacy of many new cancer drugs. Technologies and innovations in diagnostic devices have advanced to the stage where the methodology, accuracy, and clinical relevance of the test results make them feasible for use in a clinical setting in oncology. Yet the definition of Precision Medicine – the right medicine at the right dose for the right patient at the right time – encompasses so much more than just finding the somatic mutation target of a new cancer drug. With the increase in antibacterial agent resistance and a decreasing antibacterial pipeline, there is a need for coordinated efforts to promote appropriate use of antibacterial agents. Such “antibacterial agent stewardship” measures encourage the appropriate use of antimicrobials by promoting the selection of the optimal drug regimen. Clearly, this sounds an awful lot like the Precision Medicine ‘right drug at the right dose for the right patient at the right time’. Precision Medicine can help solve the crisis of antimicrobial resistance (AMR) by changing the way antibacterial agents are developed and prescribed.