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Cognoscienti

Ready for a Dose of Reality?

New laboratory and point-of-care tests are emerging to help physicians refine dosing of expensive and powerful biologics drugs, with the aim of bringing relief...

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20/20

From chromosome ends to science advocacy

Elizabeth Blackburn, PhD, began her pioneering studies of the cap-like ends of chromosomes, called telomeres, some four decades ago. Then a molecular mystery, telomeres...

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Cognoscienti

Realizing the Value of Precision Medicine: Today

For eight years, a group of 200 healthcare experts from six different stakeholder groups set aside their competitive agendas to search for an answer...

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Cognoscienti

Differentiation of Precision Medicine-Advancing Care Through Pharmacogenomics at Mayo Clinic

Mayo Clinic is an integrated multi-specialty group medical practice. The individual components operate under the auspices of Mayo Foundation, the not-for-profit parent organization. The...

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Cognoscienti

Realizing the Potential of Precision Oncology

As we approach the 20th anniversary, in 2018, of the approval of Herceptin, the field of precision oncology has never been more exciting and...

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Cognoscienti

Pharmacogenomics: Making the case for Primum non nocere

As a practicing clinician and an educator, I consistently arrive at crossroads when I need to make therapeutic choices. This often is done in...

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Field Notes

The first challenge of any population-scale research study is building a cohort of engaged participants.

The first challenge of any population-scale research study is building a cohort of engaged participants. But once that major feat is accomplished, there’s a...

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Dr. Stephen Kingsmore – a vision for transforming medicine with rapid genome sequencing

Dr. Stephen Kingsmore, MD, DSc, is the President and CEO of the Rady Pediatric Genomics and Systems Medicine Institute. Shawn Baker CSO of AllSeq...

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Precision Tools

Innovative Methodologies to Drive Enrollment of Molecularly Defined Patient Populations for Diagnostic- Enabled Basket Studies

Today, the genomic profile of a patient’s tumor may be as important, if not more so, than the tissue of origin. Patients whose tumors...

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Antidepressant Pharmacogenetics

The focus of this year’s World Health Organisation (WHO) world health day on April 7th was major depression. The prominence given to depression reflected...

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Mission Possible: Moving Diagnostics to the Forefront of Precision Medicine

The Journal of Precision Medicine was founded in order to bridge the gap between the evolving technology in healthcare and the clinical needs of...

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Field Notes

Personalized Medicine at FDA: 2016 Progress Report

If new drug approvals are any indication, personalized medicine is progressing steadily despite ongoing challenges in regulation, reimbursement and clinical adoption. The Personalized Medicine...

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A new disease level precision medicine model; starting with melanoma

In just a few months, the PM Connective expects to complete a new model for melanoma that will offer clinical and financial benefits in...

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Field Notes

The Diagnostics Year in Review – 2016

A patient has nothing without an accurate and timely diagnosis. Diagnostics are the glue that holds the healthcare system together. An inaccurate, missed or...